• Rob Orman

24. The COVID Vaccine with Paul Offit

World-renowned vaccine expert Paul Offit discusses where we stand with the development of a COVID-19 vaccine, challenges ahead, and how clinicians can best focus our efforts in vaccine education and advocacy.

This podcast is produced in partnership with Hippo Education.

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We discuss:

  • How the COVID vaccine is being made and where it targets the virus

  • Different variations of the vaccine

  • The normal path to vaccine development and how it's different with this one

  • Why Paul Offit would opt for wearing a mask vs getting a vaccine if he had to choose between the two

  • How to balance the urgency for the need for a vaccine with safety concerns

  • What happens in Phase 1, 2, and 3 trials

  • Likelihood the vaccine will be rushed to market

Guest Bio: Paul Offit is a pediatrician specializing in infectious diseases and an expert on vaccines, immunology, and virology. He is the co-inventor of a rotavirus vaccine that has been credited with saving hundreds of lives every day. Offit is the Maurice R. Hilleman professor of vaccinology, professor of pediatrics at the Perelman School of Medicine at the University of Pennsylvania and director of The Vaccine Education Center at Children's Hospital of Philadelphia (CHOP). Offit is currently a member of National Institutes of Health (NIH) working group on vaccines, a subgroup of the "Accelerating COVID-19 Therapeutic Interventions and Vaccines" (ACTIV) comprised of experts to combat COVID-19. He is also a member of the FDA's Vaccines and Related Biological Products Advisory Committee (VRBPAC). Previously, he was a member of the Centers for Disease Control and Prevention's (CDC) Advisory Committee on Immunization Practices. Offit is a board member of Vaccinate Your Family and Autism Science Foundation. "Overkill" is his 11th book.


  • O’Callaghan KP, Blatz AM, Offit PA. Developing a SARS-CoV-2 Vaccine at Warp Speed. JAMA. 2020;324(5):437–438. doi:10.1001/jama.2020.12190

  • Lurie N, Sharfstein JM, Goodman JL. The Development of COVID-19 Vaccines: Safeguards Needed. JAMA. 2020;324(5):439–440. doi:10.1001/jama.2020.12461

  • Chugh T. Timelines of COVID-19 vaccines. Curr Med Res Pract. 2020;10(4):137-138. doi:10.1016/j.cmrp.2020.07.009

  • Amanat F, Krammer F. SARS-CoV-2 Vaccines: Status Report. Immunity. 2020;52(4):583-589. doi:10.1016/j.immuni.2020.03.007

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